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Inducibility of Metabolizing Enzymes
An important toxicologically relevant feature associated with foreign compound metabolism is the inducibility of metabolizing enzymes. Some...
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Pharmacogenomics in Drug Metabolism Enzymes and Transporters
The safe and effective use of drug therapies play a critical role in treating disease. Interindividual variability in drug metabolism and transport...
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Several lines of antioxidant defense against oxidative stress: antioxidant enzymes, nanomaterials with multiple enzyme-mimicking activities, and low-molecular-weight antioxidants
Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are well recognized for playing a dual role, since they can be either deleterious...
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Bioactivation Metabolism: Activation Enzymes
Enzymes make up the largest and most highly specialized class of protein molecules. Foreign compound-metabolizing enzymes are produced from the...
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Structure and Function of Enzymes Involved in the Biosynthesis of Tropane Alkaloids
Tropane alkaloids are found in a scattered distribution among the angiosperm families including members within the Solanaceae, Erythroxylaceae,...
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Galactosidase-catalyzed fluorescence amplification method (GAFAM): sensitive fluorescent immunohistochemistry using novel fluorogenic β-galactosidase substrates and its application in multiplex immunostaining
Multiplex immunohistochemistry/multiplex immunofluorescence (mIHC/mIF) enables the simultaneous detection of multiple markers in a single tissue...
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Inducibility of Foreign Compound Metabolic Enzymes
Induction of metabolic enzymes plays a significant role in the susceptibility of individuals to foreign compound - mediated toxicities. The family of...
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Human exposure to diesel exhaust induces CYP1A1 expression and AhR activation without a coordinated antioxidant response
BackgroundDiesel exhaust (DE) induces neutrophilia and lymphocytosis in experimentally exposed humans. These responses occur in parallel to nuclear...
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Impact of NQO1 dysregulation in CNS disorders
NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to...
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Diversified Classes of Enzyme Modulators
The structure of an enzyme is required to stabilize the conformation of the active site for achieving enzymatic function. The active site of an...
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The impact of gut bacteria producing long chain homologs of vitamin K2 on colorectal carcinogenesis
Colorectal cancer (CRC) is one of the foremost causes of cancer-related deaths. Lately, a close connection between the course of CRC and the...
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Dopamine and L-Dopa as Selective Endogenous Neurotoxins
Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine...
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Dopamine and L-Dopa as Selective Endogenous Neurotoxins
Selective neurotoxins have the ability to exert their neurotoxic effects in dopaminergic neurons. This could depend on their affinity to the dopamine...
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Insights into the α-amylase and α-glucosidase inhibition mechanism of 4-(4-hydroxyphenyl)-but-3-en-2-one from Scutellaria barbata D. Don: enzymatic kinetics, fluorescence spectroscopy and computational simulation
Diabetes mellitus has become a pandemic in modern society. Regulation of carbohydrate hydrolysis by inhibition of key-digestive enzymes is currently...
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Pristimerin in Oxidative Stress and Use in Cancer
Pristimerin is a quinone methide triterpenoid extracted from plants of the Celastraceae and Hippocrateaceae families, which has shown promising...
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A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications
Sulforaphane (SFN) is a type of phytochemical found in many cruciferous vegetables that has been shown to positively benefit the control of Type 2...
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Scaffold-Based Selective ROS Generation as Viable Therapeutic Strategies Against Cancer
Reactive oxygen species (ROS) are by-products of normal cellular metabolism and play a crucial part in cell signaling and common cellular functions....
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Hypoxia-Targeting Drugs as New Cancer Chemotherapy Agents: Molecular Insights
Solid tumors have a condition of low oxygen level, termed hypoxia. Hypoxia is regarded as one important characteristic of the tumor microenvironment....
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Role of Stem Cells and Reactive Oxygen Species in Cancer
Cancer cells produce excessive reactive oxygen species (ROS) than normal cells because of their increased metabolism and mitochondrial dysfunction....
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Role of Stem Cells and Reactive Oxygen Species in Cancer
Cancer cells produce excessive reactive oxygen species (ROS) than normal cells because of their increased metabolism and mitochondrial dysfunction....